Publications

  • Xie X, Ulici V, Alexander PG, Jiang Y, Zhang C, Tuan RS. Platelet-rich plasma inhibits mechanically induced injury in chondrocytes. J Arthroscopy. In press.
  • Mariani BD, Martin DS, Chen AF, Yagi H, Lin SS, Tuan RS.  Polymerase chain reaction molecular diagnostic technology for monitoring chronic osteomyelitis.  J Exp Orthop. 2014. Aug;1:9.
  • Lozito TP, Tuan RS.  Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors.  J Cell Mol Med. 2014. In press
  • Rackwitz L, Djouad F, Janjanin S, Nöth U, Tuan RS. Functional cartilage repair capacity of de-differentiated, chondrocyte- and mesenchymal stem cell-laden hydrogels in vitro. Osteoarthr Cartilage. 2014. Aug;22(8):1148-57.
  • Gao X, Usas A, Tang Y, Lu A, Tan J, Schneppendahl J, Kozemchak A, Wang B, Cummins JH, Tuan RS, Huard J. Are human bone marrow stem cells superior to human skeletal muscle stem cells? Both cell populations can efficiently heal bone defect but require BMP. Biomaterials. 2014. Aug;35(25):6859-70.
  • Diederichs S, Tuan RS. Functional comparison of human induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor. Stem Cells Dev. 2014. Jul 15;23(14):1594-610
  • Lin H, Cheng AWM, Alexander PG, Beck AM, Tuan RS. Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible light-activated gelation capability in both air and aqueous solution.  Tissue Engin. Part A. 2014. Sep;20(17-18):2402-2411.
  • Lin H, Lozito TP, Alexander PG, Gottardi R, Tuan RS.  Stem cell-based microphysiological system to model tissue response to interleukin-1b.  Mol Pharmaceut. 2014. Jul 7;11(7):2203-12.
  • Bobick BE, Alexander PG, Tuan RS. High efficiency transfection of embryonic limb mesenchyme with plasmid DNA using square wave pulse electroporation and sucrose buffer.  Biotechniques. 2014. Feb 1;56(2):85-89.
  • Boyette LB, Tuan RS. Adult stem cells and diseases of aging.  J Clin Med. 2014 Jan 21;3(1):88-134.
  • Boyette LB, Creasey OA, Guzik L, Lozito T, Tuan RS. Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning.  Stem Cells Transl Med. 2014. Feb;3(2):241-54.
  • Lozito TP, Jackson MW, Nesti LJ, Tuan RS. Human mesenchymal stem cells generate a distinct pericellular zone of MMP activities via binding of MMPs and secretion of high levels of TIMPs. Matrix Biol. 2013. pii: S0945-053X(13)00132-7.
  • Cui CC, Chatterjee B, Lozito T, Zhang Z, Francis RJ, Yagi H, Antosnewski LM, Sanker S, Francis D, Yu Q, San Augustin J, Puligilla C, Kelley MW, Spilliotis ET, Kwiatkowski A, Tuan RS, Pazour GJ, Hukriede NA, and Lo CW. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cystoskeleton. PLOS Biology. 2013. 11(11):e1001720
  • Lozito T, Alexander PG, Lin H, Gottardi R, Cheng AWM, Tuan RS. Osteochondral microtissue to model pathogenesis of osteoarthritis.  Stem Cell Res Ther. 2013. Dec. 4 (Suppl 1).S6.
  • Yang G, Rothrauff BB, Tuan RS.  Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm.  Birth Defects Research C: Embryo Today. 2013. Sep; 99(3):203-22
  • Yang G, Rothrauff BB, Lin H, Gottardi R, Alexander PG, Tuan RS.  Enhancement of tenogenic differentiation of human adipose stem cells by tendon-drived extracellular matrix.  Biomaterials. 2013. Dec; 34(37):9295-306.
  • Baker N, Tuan RS.  The less-often-travelled surface of stem cells: Caveolin-1 and caveolae in stem cells, tissue repair and regeneration. Stem Cell Res Ther. 2013. Jul 30; 4(4):90.
  • Jiang Y, Chen, L, Zhang S, Tong T, Zhang W, Liu W, Xu, G, Tuan RS, Heng BC, Crawford R, Xiao Y, Ouyang HW. Bioactive polyvinylpyrrolidone-iodine enhances the efficacy of bio-scaffolds for osteogenesis and osteochondral repair by promoting fibronectin deposition and MSC differentiation.  Acta Biomater. 2013. 9(9):8089-8098.
  • Tuan RS, Chen AF, Klatt BA. Cartilage regeneration. J Am Acad Orthop Surg. 2013. 21(5): 303-311
  • Alexander PG, Wang X, Song Y, Taboas J, Chen FH, Levin MJ, McCarron JA, Melvin GM, Manner PA, Tuan RS.  Development of a spring-loaded impact device to deliver injurious mechanical impact to articular cartilage surface. Cartilage. 2013. 4:(1): 52-62.
  • Tuan RS. REGENERATIVE MEDICINE IN 2012. The coming of age of musculoskeletal tissue engineering. Nature Clin Pract Rheum. 2013. Feb. 9(2):74-76
  • Lin H, Zhang D, Alexander PG, Yang G, Tan J, Cheng AW, Tuan RS. Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture. Biomaterials. 2013. Jan;34(2):331-339
  • Diederichs S, Shine KM, Tuan RS.  The promise and challenges of stem cell-based therapies for skeletal diseases: Stem cell applications in skeletal medicine: Potential, cell sources and characteristics, and challenges of clinical translation. BioEssays. 2013. 35(3):220-230.
  • Yagi H, Tan J, Tuan RS. Polyphenols suppress hydrogen peroxide-induced oxidative stress in human bone-marrow derived mesenchymal stem cells. J. Cell. Biochem. 2013. 114(5):1163-1173.
  • Jackson WM, Alexander PG, Bulken-Hoover JD, Vogler JA, Ji Y, McKay P, Nesti LJ, Tuan RS. Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth. J Tissue Eng Regen Med. 2013 Jun;7(6):443-451
  • Baker N, Zhang G, You Y, Tuan RS. Caveolin-1 regulates proliferation and osteogenic differentiation of human mesenchymal stem cells. J. Cell Biochem. 2012.113(12):3773-3787.
  • Xie X, Wang Y, Zhao C, Guo S, Liu S, Jia W, Tuan RS, Zhang C.  Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration.  Biomaterials. 2012. 33(29):7008-70
  • Lin H, Tan J, Yang G, Tuan RS.  Decellularized matrix derived from human mesenchymal stem cells enhances their proliferation, migration and multi-lineage differentiation potential.  Biomaterials. 2012. 33(18):4480-4489
  • Mueller J, Mollenhauer J, Tuan RS, Benz K. Quality control for mesenchymal stromal cells: Chondrogenesis as a standard condition? Rheum Curr Res. 2012. S3:003
  • Alexander PG, McCarron JA, Levine MJ,, Melvin GM, Murray P, Manner PA, Tuan RS. An in vivo lapine model for impact-induced injury and osteoarthritic degeneration of articular cartilage. Cartilage. 2012. 3: 323-333.
  • Rackwitz L, Eden L, Reppenhagen S, Reichert JC, Walles H, Tuan RS, Rudert M, Nöth U. Stem cell and growth factor-based regenerative therapies for avascular necrosis of the femoral head.  Stem Cell Res Ther. 2012. 3(1): 7
  • Jackson WM, Nesti LJ, Tuan RS. Mesenchymal stem cell therapy for attenuation of scar formation during wound healing.  Stem Cells Res Ther. 2012. 3(3): 20
  • Steinert AF, Rackwitz L, Gilbert F, Nöth U, Tuan RS. Clinical application of mesenchymal stem cells for musculoskeletal regeneration: Current status and perspectives. Stem Cells Transl Med. 2012. 1(3):237-47.
  • Bulken-Hoover JD, Jackson WM, Ji Y, Volger JA, Tuan RS, Nesti LJ. Inducible expression of neurotrophic factors by mesenchymal progenitor cells derived from traumatically injured human muscle. Mol Biotechnol. 2012. 51(2):128-36.
  • Lozito TP, Tuan RS. Endothelial cell microparticles act as centers of matrix metalloproteinase-2 (MMP-2) activation and vascular matrix remodeling. J Cell Physiol. 2012. 227(2):534-49.
  • Jackson WM, Nesti LJ, Tuan RS. Clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med. 2012 Jan;1(1):44-50
  • Norian JM, Owen CM, Taboas J, Korecki C, Tuan RS, Malik M, Catherino WH, Segars JH. Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma. Matrix Biol. 2012 Jan;31(1):57-65
  • Tuan RS. Current trends and new technologies in developmental toxicology. Birth Defects Res C Embryo Today. 2011 Dec;93(4):289-90
  • Haleem-Smith H, Calderon R, Song Y, Tuan RS, Chen FH. Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human mesenchymal stem cells. J Cell Biochem. 2011. 113(4): 1245-1252.
  • Giri J, Li W-J, Tuan RS, Cicerone MT.  Stablization of proteins by nanoencapsulation in sugar-glass for tissue engineering and drug delivery applications.  Adv Mater. 2011; 23(42):4861-7.
  • Haleem-Smith H, Argintar E, Bush C, Hampton D, Postma WF, Chen FH, Rimington T, Lamb J, Tuan RS.  Biological responses of human mesenchymal stem cells to titanium wear debris particles.  J Orthop Res. 2011. 30(6): 853-863.
  • Bergin PF, Doppelt JD, Kephart CJ, Benke MT, Graeter JH, Holmes AS, Haleem-Smith H, Tuan RS, Unger AS. Comparison of minimally invasive direct anterior versus posterior total hip arthroplasty based on inflammation and muscle damage markers. J Bone Joint Surg Am. 2011 Aug 3;93(15):1392-8.
  • Tuan, RS. Role of adult stem/progenitor cells in osseointegration and implant loosening. Int J Oral Maxillofac Implants. 2011;26 Suppl:50-62
  • Locke P, O'Brien T, Tuan RS. Stem Cell Research & Therapy marks its first anniversary. Stem Cell Res Ther. 2011 May 6;2(3):22
  • Wang D, Taboas JM, Tuan RS. PTHrP overexpression protects chondrocytes from strain-induced hypertrophy. Osteoarthr Cart. 2011. Feb;19(2):213-21.
  • Coleman CM, Scheremeta BH, Boyce AT, Mauck RL, Tuan RS. Delayed fracture healing in Growth-Deficient Factor-5 deficient mice.  Clin Orthop Rel Res. 2011.Oct;469(10): 2915-24
  • Jackson WM, Aragon AB, Onodera J, Koehler SM, Ji Y, Bulken-Hoover J, Vogler JA, Tuan RS, Nesti LJ. Cytokine expression in muscle following traumatic injury. J Orthop Res. 2011. 29(10):1613-20.
  • Jackson WM, Lozito TP, Djouad F, Kuhn N, Nesti LJ, Tuan RS.  Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue.  J Cell Mol Med.  2011. 15(11):2377-88.
  • Lozito TP, Tuan RS. Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs. J Cell Physiol. 2011. 226: 385-96
  • Nöth U, Rackwitz L, Steinert AF, Tuan RS. Cell delivery therapeutics for musculoskeletal regeneration. Adv Drug Deliv Rev. 2010. 62:765-83
  • Alexander PG, Tuan RS.  Role of environmental factors in axial skeletal dysmorphogenesis. Birth Defects Res C Embryo Today. 2010 Jun;90(2):118-32
  • Mueller MB, Fischer M, Zellner J, Berner A, Dienstknecht T, Prantl L, Kujat R, Nerlich M, Tuan RS, Angele P. Hypertrophy in mesenchymal stem cell chondrogenesis: Effect of TGF-beta isoforms and chondrogenic conditioning. Cells Tiss Organs. 2010. 92(3):158-66.
  • Alongi DJ, Yamaza T, Song Y, Fouad AF, Romberg EE, Shi S, Tuan RS, Huang GT. Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential. Regen Med. 2010. 5(4):617-31.
  • Korecki C, Taboas J, Tuan RS, Iatridis J. Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation potentially toward a young nucleus pulposus phenotype.  Stem Cell Res Ther. 2010. 1(2):18.
  • Petrie Aronin CE, Tuan RS. Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells. Birth Defects Res C Embryo Today. 2010 90:67-74.
  • Jackson WM, Nesti LJ, Tuan RS. Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells. Expert Opin Biol Ther. 2010 Apr;10(4):505-17.
  • Djouad F, Jackson W, Bobick B, Huang G, Janjanin S, Rackwitz L, Song Y, Tuan RS.  Activin A expression regulates multipotency of mesenchymal progenitor cells.  Stem Cell Res Ther. 2010. 1(2):11.
  • Bobick BE, Matsche AI, Chen FH, Tuan RS. Opposing roles of ERK5 and ERK1/2 signaling pathways in regulating chondrogenesis of adult human mesenchymal progenitor cells. J Cell Physiol. 2010. 224(1):178-86.
  • Maher SA, Mauck RL, Rackwitz L, Tuan RS. A nanofibrous cell-seeded hydrogel promotes integration in a cartilage gap model. J Tissue Eng Regen Med. 2010. 4:25-29
  • Bobick BE, Tuan RS, Chen FH. The intermediate filament vimentin regulates chondrogenesis of adult human bone marrow-derived multipotent progenitor cells. J Cell Biochem. 2010. 109:265-276.
  • Yan X, Qin H, Qu C, Tuan RS, Shi S, Huang GT. iPS cells reprogrammed from mesenchymal-like stem/progenitor cells of dental tissue origin. Stem Cells Dev. 2010. 19(4):469-80
  • Bergin PF, Doppelt JD, Hamilton WG, Mirick GE, Jones AE, Sritulanondh S, Helm JM, Tuan RS. Application of ribosomal ribonucleic acid-based real-time reverse transcription polymerase chain reaction for the rapid detection of periprosthetic joint infections. J Bone Joint Surg Am. 2010. 92: 654-663.
  • Kuhn NZ, Tuan RS. Regulation of stemness and stem cell niche of mesenchymal stem cells: Implications in tumorigenesis and metastasis.  J. Cell. Physiol. 2010. 222:268-277
  • Lai Y, Sun Y, Skinner CM, Son EL, Lu Z, Tuan RS, Jilka RL, Ling J, Chen XD. Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells. Stem Cells Develop. 2010. 19(7):1095-1107.

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Chapters/Reviews

 

  • Klatt BA, Chen AF, Tuan RS. Arthritis and other cartilage disorders. In: Cannada LK, editor. Orthopaedic Knowledge Update 11. American Academy of Orthopaedic Surgeons, Rosemont. 2014.  Chapter 18, pp. 207-222.
  • Alexander PG, Gottardi R, Lin H, Lozito TP, Tuan RS. Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases. Expt Biol Med. 2014. Sep;239(9):1080-95.
  • Lv, FJ, Tuan RS, Cheung KMC, Leung VYL.  The identity of mesenchymal stem cells. Stem Cells. 2014. Jun;32(6):1408-19.
  • Xie X, Zhang C, Tuan RS.  Biology of platelet-rich plasma and its clinical application in cartilage repair.  Arthr Res Ther.  2014.  16:204
  • Rothrauff BB, Tuan RS. Cellular therapy in bone-tendon interface regeneration.  Organogenesis. 2014. 10:1.
  • Boyette LB, Tuan RS. Maintaining the adult stem cell to combat diseases of aging.  J Clin Med. 2014. 3(1):88-134.
  • Alexander PG, Hofer HR, Clark KL, Tuan, RS. Mesenchymal Stem Cells.  In: Lanza R, Langer R, Vacanti JP. Principles of Tissue Engineering. 4th Edition. Elsevier. 2014.  pp. 1171-1199.
  • Yang G, Rothrauff BB, Tuan RS.  Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm.  Birth Defects Research C: Embryo Today. 2013. 99(3):203-22
  • Lozito T, Tuan RS. Crosstalk between MSCs and their environments.  In: Mesenchymal Stromal Cells: Biology and Clinical Applications. (Hematti R, Keating A, Eds) New York: Springer. 2013, pp 169-192
  • Tuan RS, Chen AF, Klatt BA. Cartilage regeneration. J Am Acad Orthop Surg. 2013 May;21(5):303-11.
  • Locke P, O'Brien T, Tuan RS. Three years of Stem Cell Research & Therapy.  Stem Cell Res Ther. 2013 May 1;4(3):46
  • Baker N, Tuan RS.  The less-often-travelled surface of stem cells: Caveolin-1 and caveolae in stem cells, tissue repair and regeneration. Stem Cell Res Ther. 2013. 4:90
  • Bean AC, Tuan RS.  Stem cells and nanotechnology in tissue engineering and regenerative medicine. In Micro and Nanotechnologies in Engineering Stem Cells and Tissues (Ramalingam M, Jabbari E, Ramakrishna S, Khademhosseini A, Eds.) 2013. p.1-26
  • Tuan RS, Mauck RL. Articular cartilage repair and regeneration.  In: Einhorn T, O’Keefe R, Chu C, Jacobs J, editors.  Orthopaedic Basic Science, 4th Edition. 2013.  pp 309-327.
  • Tuan RS. REGENERATIVE MEDICINE IN 2012. The coming of age of musculoskeletal tissue engineering. Nature Clin Pract Rheum. 2013. Feb. 9(2):74-76.
  • Locke P, Tuan RS, O'Brien T. Stem Cell Research and Therapy in 2012. Stem Cell Res Ther. 2012;3(2):16.
  • Diederichs S, Shine KM, Tuan RS.  Cell-based therapies for skeletal tissue.  BioEssays. 2013. 35(3):220-230.
  • Mueller J, Mollenhauer J, Tuan RS, Benz K. Quality control for mesenchymal stromal cells: Chondrogenesis as a standard condition? Rheum. Curr Res. 2012. S3:003
  • Tuan RS.  Current trends and new technologies in developmental toxicology. Birth Defects Res C Embryo Today. 2011 Dec;93(4):289-90.
  • Bergin PF, Tuan RS. New Technologies for Diagnosing Orthopaedic Infections.  2011.  AAOS NOW.  May, 2011.
  • Mueller MB, Tuan RS. Anabolic/catabolic balance in pathogenesis of osteoarthritis. 2011. Phys. Med. Rehab. 3(6 Suppl):S3-S11.
  • Petrie Aronin CE, Kuhn NZ, Tuan RS. Tissue engineering and selection of cells. In: P. Ducheyne, K. Healy, D. Hutmacher, J. Kirkpatrick, Eds Comprehensive Biomaterials. Vol. 5. 2011. Oxford: Elsevier.  pp. 81-93.
  • Fortier LA, Tuan RS. Stem cells in regenerative surgical strategy.  In: Tobias & Johnson, editors. Small Animal Surgical Practice. Maryland Heights: Elsevier; 2011. Vol. 1, Chapt. 4.
  • Petrie Aronin CE, Tuan RS. Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells. Birth Defects Res C Embryo Today. 2010 Mar;90(1):67-74.
  • Nöth U, Rackwitz L, Steinert AF, Tuan RS.  Principles of tissue engineering and cell- and gene-based therapy.  In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology, 5th Edition. 2010. Philadelphia: Elsevier.  Chapter 18.
  • Nöth U, Rackwitz L, Steinert AF, Tuan RS.  Cell delivery therapeutics for musculoskeletal regeneration. Adv Drug Deliv Rev. 2010. 62(7-8):765-83.
  • Kuo CK, Marturano JE, Tuan RS.  Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs. Sports Med Arthros Rehab Ther Tech.  2010. 2(1):20.
  • Alexander PG, Tuan RS.  Role of environmental factors in axial skeletal dysmorphogenesis. Birth Defects Res C Embryo Today. 2010 Jun;90(2):118-32